Dermatologic and Dermatopathologic Features of Monogenic Autoinflammatory Diseases
نویسندگان
چکیده
منابع مشابه
Monogenic autoinflammatory diseases.
During the past 15 years, a growing number of monogenic inflammatory diseases have been described and their respective responsible genes identified. The proteins encoded by these genes are involved in the regulatory pathways of inflammation and are mostly expressed in cells of the innate immune system. Diagnosis remains clinical, with genetic confirmation where feasible. Although a group of pat...
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Monogenic autoinflammatory diseases are a group of hereditary disorders characterized by a clinical and biological inflammatory syndrome in which there is little or no evidence of autoimmunity. The discovery of the first causative gene in 1997 was rapidly followed by the identification of many others from the same group. The mutated proteins can be directly or indirectly involved in the regulat...
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Results Interleukin (IL)-17, IL-22, and IL-23 were all significantly raised in our cohort of AIDs compared to controls, whereas IL-1b, IL-6, IL-8, and TNF-a levels were differently heighten among the diseases. Thus, the cytokine pattern may help to distinguish the AIDs in term of number of enhanced cytokines, as follow BS<TRAPS<FMF<AOSD. Moreover, the upregulation of Th17-related cytokines may ...
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Introduction Autoinflammatory diseases (AIDs) represent a group of monogenic disorders, related to mutations in genes encoding proteins involved in the regulation of inflammatory responses. The aims of therapy in AIDs patients are controlling disease activity, improving patient’s quality of life and preventing long-term complications. Biological agents have recently changed the natural history ...
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ژورنال
عنوان ژورنال: Frontiers in Immunology
سال: 2019
ISSN: 1664-3224
DOI: 10.3389/fimmu.2019.02448